Background: To evaluate the short-term reproducibility of diurnal intraocular pressure (IOP) and ocular perfusion\npressure (OPP) measurements in normal volunteers, untreated normal-tension glaucoma (NTG) and primary open-angle\nglaucoma (POAG) patients.\nMethods: Fifty-four healthy volunteers (control group), 67 NTG patients and 54 POAG patients were recruited. The IOPs\nof both eyes were measured with a Goldmann applanation tonometer at 3-h intervals over 2 consecutive days. Blood\npressure (BP) measurements were collected at the same times. The mean IOP/OPP, peak IOP/OPP, trough IOP/OPP and\nIOP/OPP fluctuations on each day were also calculated. The intraclass correlation coefficients (ICCs) were used to\nevaluate the reproducibilities.\nResults: In the control group, the ICCs of mean IOP, peak IOP, trough IOP and IOP fluctuation were 0.921, 0.889, 0.888,\nand 0.661, respectively, and the ICCs of the mean OPP, peak OPP, trough OPP and OPP fluctuations were 0.962, 0.918,\n0.953, and 0.680, respectively. In the NTG group, the ICCs of the mean IOP, peak IOP, trough IOP and IOP fluctuation\nwere 0.862, 0.741, 0.798, and 0.290, respectively, and the ICCs of the mean OPP, peak OPP, trough OPP and OPP\nfluctuations were 0.947, 0.828, 0.927, and âË?â??0.008, respectively. In the POAG group, the ICCs of the mean IOP, peak IOP,\ntrough IOP and IOP fluctuation were 0.857, 0.666, 0.808, and 0.546, respectively, and the ICCs of the mean OPP, peak\nOPP, trough OPP and OPP fluctuation were 0.934, 0.842, 0.910, and 0.093, respectively.\nConclusion: The IOP measurements within a single day were not highly reproducible in the short-term. The normal\nvolunteers exhibited better IOP and OPP reproducibilities than the glaucoma patients. The IOP and OPP fluctuations\ncould not be accurately evaluated based on the IOP or OPP measurements within a single day.\nAbbreviations: AGIS, Advanced glaucoma intervention study; BP, Blood pressure; CCT, Central corneal thickness;\nCLS, Contact lens sensor; DBP, Diastolic blood pressure; GAT, Goldmann applanation tonometer; HR, Heart rate;\nICCs, Intraclass correlation coefficients; IOP, Intraocular pressure; MD, Mean deviation; NTG, Normal-tension glaucoma;\nOHT, Ocular hypertension; OPP, Ocular perfusion pressure; POAG, Primary open-angle glaucoma; SBP, Systolic blood\npressure; TSNIT, Temporal, superior, nasal, inferior, and temporal; VF, Visual field
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